James Cook III
NFL Injury Report

James Cook III Injury Status

Buffalo Bills • RB
Latest Injury Status
active
A

Cook put together another highly efficient night that saw him gain significant chunks of yards on multiple carries, and which featured his fifth rushing touchdown of the season on a 17-yard run in the later portion of the second quarter. However, Cook dodged what would have been a major blemish on his night -- a lost fumble at the Rams' 20-yard line in overtime -- when Josh Allen subsequently mounted a successful game-winning drive following a blocked field goal by Buffalo's special teams. Cook will take 532 rushing yards and an average of 5.6 yards per carry into a Week 6 road matchup against the Raiders on Sunday.

Injury Details

Body Part
—
Location
—
Side
—
Expected Return
Not announced

Betting Research

Player availability can affect minutes, usage, matchup assignments, team totals and player-prop markets. Compare the latest injury information with current prices before making a betting decision.

James Cook III Injury History

October 14, 2026
active
Cook rushed 10 times for 121 yards and a touchdown and brought in his only target for seven yards in the Bills' 37-34 overtime win over the Rams on Monday night. He also committed two fumbles, losing one.
October 13, 2026
active
Cook rushed 12 times for 75 yards and a touchdown and brought in both targets for eight yards in the Bills' 29-26 loss to the Patriots on Sunday.
October 4, 2026
active
Cook rushed 24 times for 154 yards and a touchdown and failed to bring in his only target in the Bills' 24-16 win over the Chargers on Sunday. He also lost a fumble.
September 27, 2026
active
Cook rushed 21 times for 135 yards and a touchdown and brought in one of three targets for four yards in the Bills' 41-31 win over the Lions on Thursday.
September 18, 2026
active
Cook rushed 13 times for 57 yards and caught three of four targets for 12 yards in Sunday's 36-31 win over the Texans.
September 13, 2026
active
Cook didn't play during Buffalo's exhibition win over Pittsburgh on Thursday.
August 29, 2026
active
Cook carried the ball five times for 21 yards in Saturday's 29-14 preseason win over the Panthers.

Latest James Cook III Injury Updates

This page tracks available injury information for James Cook III, including reported status, injury details, expected return information and updates that may be relevant when evaluating NFL betting markets.

Injury designations can change close to game time. Check the latest market prices and confirmed player availability before placing a wager.