James Thompson Jr.
NFL Injury Report

James Thompson Jr. Injury Status

San Francisco 49ers • DT
Latest Injury Status
active
A

Thompson hasn't played since Week 2 against the Dolphins after playing 35 percent of the defensive snaps across the first two weeks of the season. He'll slide back into his depth role along the defensive line behind Osa Odighizuwa and Naquan Jones.

Injury Details

Body Part
—
Location
—
Side
—
Expected Return
Not announced

Betting Research

Player availability can affect minutes, usage, matchup assignments, team totals and player-prop markets. Compare the latest injury information with current prices before making a betting decision.

View James Thompson Jr. Props Compare Odds Expert Picks

James Thompson Jr. Injury History

October 22, 2026
active
Thompson (ankle) doesn't carry an injury designation into Monday night's game against the Commanders.
October 18, 2026
active
October 17, 2026
questionable • Ankle
Sprain
Thompson (ankle) could return in Week 6 against Washington, Matt Barrows of The Athletic reports.
October 13, 2026
questionable • Ankle
Sprain
questionable
October 12, 2026
out • Ankle
Sprain
out
October 12, 2026
out • Ankle
Sprain
inactive
October 11, 2026
out • Ankle
Sprain
Thompson (ankle) has been ruled out for Sunday's game against the Seahawks.
October 10, 2026
out • Ankle
Sprain
out
October 9, 2026
doubtful • Ankle
Sprain
doubtful
October 6, 2026
out • Ankle
Sprain
Coach Kyle Shanahan said Monday that Thompson (ankle) is not expected back for Week 5, Cam Inman of The San Jose Mercury News reports.
October 6, 2026
out • Ankle
Sprain
out
October 5, 2026
out • Ankle
Sprain
inactive
October 4, 2026
out • Ankle
Sprain
Thompson (ankle) won't play in San Francisco's Week 4 matchup versus the Broncos, Jennifer Lee Chan of NBC Sports Bay Area reports.
September 29, 2026
out • Ankle
Sprain
out
September 28, 2026
out • Ankle
Sprain
inactive
September 27, 2026
out • Ankle
Sprain
Thompson (ankle) is listed as out for Sunday's game against Arizona.
September 26, 2026
out • Ankle
Sprain
out
September 25, 2026
doubtful • Ankle
Sprain
Thompson suffered a high-ankle sprain during Sunday's 35-13 win over Miami, David Lombardi of SFStandard.com reports.
September 21, 2026
doubtful • Ankle
Sprain
doubtful
September 21, 2026
questionable • Ankle
Not Specified
Thompson (ankle) is questionable to return to Sunday's contest against Miami, Eric Branch of the San Francisco Chronicle reports.
September 12, 2026
active
September 10, 2026
questionable • Hamstring
Not Specified
questionable

Latest James Thompson Jr. Injury Updates

This page tracks available injury information for James Thompson Jr., including reported status, injury details, expected return information and updates that may be relevant when evaluating NFL betting markets.

Injury designations can change close to game time. Check the latest market prices and confirmed player availability before placing a wager.